Biotech Bar
钰沐菡_漫谈医药以轻松愉快的方式聊聊AI制药
| Publishes | Twice monthly | Episodes | 8 | Founded | 3 years ago |
|---|---|---|---|---|---|
| Language |  ZH-CN | Number of Listeners | Categories | ScienceNatural SciencesTechnology |
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Latest Episodes
本期节目主要围绕 Atlas Adventure 合伙人Bruce Booth 的2025年度总结，聊了聊生物医药行业的发展趋势，尤其是中国公司在全球医药领域的竞争力提升。还有生物医药行业的投资和创业，投资人在当前经济环境下的投资逻辑，比如对于平台型公司和资产型公司的考量。最后展望了生物医药行业未来的发展方向，包括新靶点的发现和新生态的构建，多维度视角下的项目选择和投资决策等等。
本期人物：钰沐菡 ，「钰沐菡 」平台创始人旺德福，「Biotech Bar 」联合策划人、常驻嘉宾乔晶博士，药企高级... more
哈喽大家好，我是钰沐菡，欢迎回来。我们的播客在段更了一段时间之后， 终于要重新跟大家见面了。接下来的几期，我们会聚焦小分子药物领域，跟大家聊一下最近很火的减肥药，靶向GLP1受体的小分子激动剂，靶向降解药物，分子胶和PROTAC等小分子药物领域的进展。
本期节目，我们来聊一聊最近很火的药物靶点GLP1R (glucagon-like peptide-1 receptor)，具体来聊一聊GLP1R激动剂开发的历史，小分子激动剂最近的进展，结构生物学以及近些年冷冻电镜技术得快速发展对于GLP1受体以... more
小核酸药物在当前医药行业中非常火热，但在递送技术的创新层面依然存在困境，已上市的小核酸药物仅能针对肝脏靶点。小核酸抗体偶联药物（Antibody-oligonucleotide conjugates，AOC）和小核酸多肽偶联药物（Peptide-oligonucleotide conjugates，POC）利用抗体或多肽将治疗性寡核苷酸递送至特定细胞或组织，将抗体/多肽的组织特异性优势，与小核酸的靶点特异性优势相结合，可一定程度上用于解决目前小核酸药物仅能通过脂质纳米颗粒（LNP）、N-乙酰半乳... more
"靶向分子+偶联药物”模式（XDC）由靶向分子、连接体 (linker)、效应分子（payload）组成，识别肿瘤细胞后内吞进入溶酶体后释放药物，通过诱导微管抑制、DNA损伤引起细胞凋亡，同时也通过旁观者效应杀死周围肿瘤细胞。
抗体偶连药物 （ADC）中使用的payload一般是细胞毒性化合物。目前最常用的payload主要针对DNA或微管蛋白，针对DNA的有：卡利霉素、双卡霉素、PBD、SN-38和DXd，针对微管蛋白的有 Auristatins（MMAE、MMAF） 和美登素衍生物（DM2，... more
Chart Rankings
How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.
Apple Podcasts | #81 | China/Technology |
Apple Podcasts | #241 |  Hong Kong/Technology |
Apple Podcasts | #250 |  Philippines/Technology |
Audience Metrics
Listeners, social reach, demographics and more for this podcast.
| Listeners per Episode | Gender Skew | Location | |||
|---|---|---|---|---|---|
| Interests | Professions | Age Range | |||
| Household Income | Social Media Reach | ||||
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Biotech Bar launched 3 years ago and published 8 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.
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