聊聊Sci
淼淼Elva聊聊Science和Nature！
| Publishes | Daily | Episodes | 310 | Founded | 6 months ago |
|---|---|---|---|---|---|
| Language | Norwegian | Number of Listeners | Category | Science |
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Latest Episodes
这篇研究深入探讨了在持续抗原刺激下，肿瘤引流淋巴结如何维持干细胞样CD8+ T细胞（TSL细胞）的存活和功能。研究结果表明，这些TSL细胞聚集在树突状细胞附近的特定抗原提呈生态位中，并持续接收T细胞受体信号，但同时表达高水平的PD-1抑制分子。令人意外的是，持续的抗原信号并非导致细胞走向终末效应分化，而是在抑制性PD-1通路的调控下，促进了TSL细胞的增殖和自我更新。该调控机制支持了具有最高T细胞受体亲和力的克隆选择性扩增和保留，从而确保了高效能效应细胞的持续供应。然而，研究发现PD-1检查点阻... more
该研究利用一个包含跨越数十年的近45万狩猎记录的庞大数据集，对亚马逊地区的野生肉类消费和生产力进行了全面的地理空间评估。结果显示，野生肉类为近1100万农村居民提供了至关重要的蛋白质和微量营养素，对保障其营养安全至关重要。研究估计该地区每年可食用野生肉产量约为0.34百万吨，其中仅20个动物分类群就贡献了提取生物量的绝大部分。然而，在遭受严重森林砍伐、人口密度高或靠近城市中心的地区，人均野生肉类的可获得性显著下降，生产力降幅高达67%。因此，作者强调迫切需要维护森林生态系统的完整性，以此来保护生... more
本研究深入探究了人类颞上回（STG）如何处理语音，旨在区分独立于语言经验的普遍机制和依赖于学习的特定语言机制。通过对单语和双语参与者进行高密度皮层电图（ECoG）记录，研究人员发现STG对母语和外语均表现出相似的总体活动，并且一致地编码了共享的声学-语音特征。然而，只有在听母语时，STG才显示出对更高级别语言结构信息的显著增强编码，包括词边界、词频和特定于语言的音序统计信息。在双语者中，这种强大的词汇和序列信息编码则体现在所有熟悉的语言中，且使用相同的神经元群体。这些结果表明，语言经验会动态地影... more
这篇文章提供了对克罗恩病（CD）瘘管的分子基础进行理解的高分辨率空间和单细胞图谱，该瘘管是一种导致高发病率的异常隧道结构。通过对68个瘘管的分析，研究确定了独特的细胞群，特别是瘘管相关基质（FAS）成纤维细胞，它们以同心层形式排列，驱动着瘘管的形成和持续。FAS细胞被认为是疾病的关键驱动因素，它们通过复杂的免疫-基质串扰和上皮细胞再生信号，指导着激烈的细胞外基质（ECM）重塑。此外，研究揭示了发育转录因子如TWIST1和OSR2参与调控FAS细胞功能，促进了组织的侵袭性。与溃疡中的FAS样细胞不... more
Reviews
- 我最喜欢的播客之一，谢谢淼淼Elva
One of my favorite podcasts, thanks, 淼淼Elva
Apple Podcasts5TylerZou
Chinaa month ago - AI生成播客
选题挺好，真人聊就好了
Apple Podcasts1Yuantai SunChina3 months ago
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Apple Podcasts | #34 | China/Science |
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