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Smart Biotech Scientist | Master Bioprocess CMC Development, Biologics Manufacturing & Scale-up, Cell Culture Innovation

David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist
Biotechnology
Stakeholder Management
Impedance Flow Cytometry
Bioprocess Development
Bioprocessing
Biologics
CMC Development
Bead-Based Assays
Biologics Manufacturing
Biopharmaceuticals
Artificial Intelligence
Synthetic Biology
Cell Factories
Regulatory Compliance
Quality Control
Cultivated Meat
High Throughput Screening
Single-Cell Analysis
Cell and Gene Therapies
Cell Culture

The Go-to Podcast for Biotech Scientists Who Want to Master Biopharma CMC Development and Biomanufacturing.

**TOP 10 LIFE SCIENCES PODCAST**

Are you ready to simplify bioprocess development and scale with confidence to reduce time to market?

Are you feeling overwhelmed by the complexity and guesswork of biologics development and biomanufacturing?

Do you wish you had more time to enjoy the beauty o... more

PublishesDailyEpisodes226Founded2 years ago
Number of ListenersCategories
Life SciencesScience

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Artwork for Smart Biotech Scientist

Latest Episodes

Imagine treating cancer with the precision of a guided missile—delivering radioactive payloads directly to tumor cells. Radiopharmaceuticals are reshaping cancer diagnostics and therapy by pairing tumor-targeting molecules with radioisotopes for diag... more

The cultivated meat industry has captured headlines and struggled with economics. Meanwhile, plant cell biomanufacturing is quietly solving the cost equation and approaching commercial launch. The question isn't whether cellular agriculture can work ... more

What if the chocolate industry's reliance on equatorial farms—and the deforestation that comes with it—could be eliminated entirely? Plant cell bioreactors are doing that, producing real cacao without a single tree. But this isn't just about chocolat... more

What happens when we move beyond oversimplified cell cultures and truly embrace the complexity of human biology? In this episode of the Smart Biotech Scientist Podcast, we explore how advanced 3D cell models are reshaping preclinical research—recreat... more

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Recent Guests

Steven Lang
Expert in cellular agriculture and plant cell culture
California Culture
Episode: 224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2
Catarina Brito
Expert in advanced cell models and their applications in biopharmaceutical research
iBET
Episode: 222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2
Troy Lionberger
Chief Business Officer at A-Alpha Bio
A-Alpha Bio
Episode: 219: From 10,000 Structures to 1.8 Billion Interactions: Breaking the Data Bottleneck to Engineer Efficacious Therapeutics with Troy Lionberger - Part 1
Masafumi Osawa
Pioneering biomanufacturing expert at KAICO
KAICO
Episode: 217: Silkworm Biomanufacturing: From Ancient Silk Production to Phase I Vaccine Trials with Masafumi Osawa - Part 1
Ilya Burkov
Global head of Healthcare and Life Sciences growth at Nebius AI
Nebius AI
Episode: 215: From Data Silos to Autonomous Biomanufacturing: Digital Twins and AI-Driven Scale-Up with Ilya Burkov - Part 1
Giuseppe Licari
Principal Scientist in Computational Structural Biology
Merck KGaA
Episode: 213: From Developability to Formulation: How In Silico Methods Predict Stability Issues Before the Lab with Giuseppe Licari - Part 1
Jesús Zurdo
A veteran in drug discovery and technology development, and a leukemia survivor
Episode: 211: When the Innovator Becomes the Patient: Manufacturing Reality vs. Patient Urgency with Jesús Zurdo - Part 1
Irina Ramos
A downstream processing powerhouse with extensive experience in CMC projects and was involved in the transfer of the AstraZeneca COVID vaccine globally.
AstraZeneca
Episode: 209: From Batch to Continuous: Building Innovation Culture in Conservative Biotech Environments with Irina Ramos - Part 1
Tom Rizzo
Professor emeritus at EPFL and CSO at Isospec Analytics
Isospec Analytics
Episode: 208: Cryogenic Infrared Ion Spectroscopy: From Mass Spec Limitations to Molecular Precision with Tom Rizzo - Part 2

Host

David Brühlmann
Host of the podcast and a biotech entrepreneur and strategic advisor who collaborates with C-level biopharma leaders to tackle major challenges in biomanufacturing, especially relating to reducing costs and improving accessibility of therapies.

Reviews

4.9 out of 5 stars from 30 ratings
  • Good stuff !

    I am enjoying this podcast and always learn a thing or two! Thanks David!

    Apple Podcasts
    5
    Rob78_13
    United Statesa year ago
  • Insightful!

    I love my weekly dose of the Smart Biotech Scientist podcast! I enjoy hearing and learning from my peers in the biopharmaceutical development field, gaining new insights and perspectives on CMC development challenges, tech, and strategies. The host is knowledgeable and engaging, bringing expert guests who share their cutting-edge strategies and real-world experiences. Whether you’re a seasoned professional or new to the field, this podcast offers practical advice and innovative solutions that c... more

    Apple Podcasts
    5
    Giulia Lambiase
    United Kingdoma year ago
  • Great interviews, good format

    David delivers a great podcasts: I like the depth of the conversations and also that the episodes have the perfect length for my commute to work👍

    Apple Podcasts
    5
    pilldipp
    Germany2 years ago
  • Deeply Refreshing Perspective

    I am really a fan of David’s content and his approach to intriguing subjects.

    Apple Podcasts
    5
    Stem Cell Guy
    United States2 years ago
  • Fantastic content!

    Great podcast! Highly recommend that anybody working in biotech listen to this podcast. David, the host, is very knowledgeable in the bio tech space. I have enjoyed the insights from the guests.

    Apple Podcasts
    5
    MatthiasV1976
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

Many reviewers have recommended it as an essential resource for anyone in the biomanufacturing field, emphasizing its relevance and insights.
Listeners appreciate the knowledge and engaging nature of the host and guests, highlighting valuable insights into complex biopharmaceutical topics.
The podcast is praised for its practical advice and ability to distill complex concepts in bioprocess development into understandable information.
Audiences enjoy the discussions that reflect real-world challenges faced in biomanufacturing and CMC development.

Chart Rankings

How this podcast ranks in the Apple Podcasts, Spotify and YouTube charts.

Talking Points

Recent interactions between the hosts and their guests.

222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2
Q: What is your advice to a smart scientist wondering how they could implement these advanced models?
Brito advises to focus on the biological question first and keep the models as simple as possible to extract beneficial insights.
222: From 2D Cultures to Advanced 3D Cell Models for Preclinical Research with Catarina Brito - Part 2
Q: Can you give us a concrete example of how modeling the tumor microenvironment in your system has revealed insights about various interactions or mechanisms?
Brito explains that in their breast cancer model, the fibroblasts contributed to resistance against antibody drug conjugates, insights only observable in the 3D model.
224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2
Q: What advice would you give to someone considering transitioning into cellular agriculture?
Look for cell culture opportunities outside cultivated meat and biopharma; explore products that can be produced from plant cells as they have a fast route to market.
224: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 2
Q: What do you see emerging and are hot technologies that are coming into this space?
A lot of supplements and other food products, particularly saffron produced from plant cell culture and potentially even cell cultured wood.
223: From Cultivated Meat to Chocolate: Rethinking Cellular Agriculture Scale-Up with Steven Lang - Part 1
Q: What is your definition of cellular agriculture?
Lang defined cellular agriculture as using cell culture to produce agricultural products, emphasizing its broader application beyond just cultivated meat.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Smart Biotech Scientist

What is Smart Biotech Scientist about and what kind of topics does it cover?

This podcast provides valuable insights tailored for biotechnology professionals, particularly those focused on bioprocess development and manufacturing. It actively addresses the complexities faced in the biopharmaceutical sector, offering listeners practical strategies to streamline processes in biologics manufacturing and reduce time to market for innovative therapies. The conversations feature industry experts sharing their knowledge and experiences, focusing primarily on key areas such as cell culture, CMC development, and the use of AI in bioprocessing. This engaging format encourages both seasoned and newcomer professionals to optimize their practices and embrace new technologies that can advance their work in the biotechnology field... more

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Which podcasts are similar to Smart Biotech Scientist?

These podcasts share a similar audience with Smart Biotech Scientist:

1. The Rest Is Politics
2. The Intelligence from The Economist
3. Business Of Biotech
4. The Long Run with Luke Timmerman

How many episodes of Smart Biotech Scientist are there?

Smart Biotech Scientist launched 2 years ago and published 226 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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What guests have appeared on Smart Biotech Scientist?

Recent guests on Smart Biotech Scientist include:

1. Steven Lang
2. Catarina Brito
3. Troy Lionberger
4. Masafumi Osawa
5. Ilya Burkov
6. Giuseppe Licari
7. Jesús Zurdo
8. Irina Ramos

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