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In the Interim...

Berry
Clinical Trials
Bayesian Statistics
Adaptive Trials
I-Spy 2
FDA
Alpha
Endovascular Therapy
Platform Trials
Trastuzumab
Pertuzumab
Adaptive Clinical Trials
Regression To the Mean
Drug Development
Interim Analyses
Adaptive Designs
Breast Cancer
Her2-Positive Breast Cancer
Bayesian Model
STEP Platform Trial
Acute Stroke

A podcast on statistical science and clinical trials. Explore the intricacies of Bayesian statistics and adaptive clinical trials. Uncover methods that push beyond conventional paradigms, ushering in data-driven insights that enhance trial outcomes while ensuring safety and efficacy. Join us as we dive into complex medical challenges and regulatory landscapes, offering innovative solutions tailore... more

PublishesWeeklyEpisodes40Founded10 months ago
Number of ListenersCategories
ScienceMedicineHealth & FitnessMathematics

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Latest Episodes

In episode 40 of "In the Interim…", Dr. Scott Berry examines the statistical, operational, and behavioral challenges of using interim analyses as triggers for funding in adaptive and seamless Phase II/III clinical trials. The episode presents a typic... more

In this episode of "In the Interim...", Dr. Scott Berry interviews Dr. Kaspar Rufibach, Co-Head of Advanced Biostatistical Sciences at Merck. The conversation tracks Rufibach’s evolution from academic training in actuarial and mathematical statistics... more

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In this episode of "In the Interim…" guest host Cooper Berry moderates a detailed discussion on the evolution and practice of Bayesian methodology in clinical trials with fellow family members Dr. Don Berry, Dr. Scott Berry, Dr. Lindsay Berry, and Dr... more

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In episode 37 of "In the Interim…", Dr. Jeff Saver, Director of the UCLA Comprehensive Stroke and Vascular Neurology Program, details his shift from behavioral neurology to clinical stroke research after early engagement with multicenter trials like ... more

YouTube

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Recent Guests

Kaspar Rufibach
Co-heading a group in Advanced Biostatistical Sciences at Merck.
Merck
Episode: Discussion with Kaspar Rufibach
Jeff Saver
Carolyn James Collins Distinguished Professor of Neurology at UCLA and Director of the UCLA Comprehensive Stroke and Vascular Neurology Program.
UCLA
Episode: A Visit with Stroke Neurologist Dr. Jeff Saver
Don Berry
Statistician and expert in clinical trial design
Episode: The Saga of the Lecanemab Adaptive Phase II Trial
Dr. Jim Albert
Emeritus professor from Bowling Green State University, expert in Bayesian statistics and sports analytics.
Bowling Green State University
Episode: Teaching Statistics and Data Science through Sports with Dr. Jim Albert
Andrew Thomson
Owner and lead consultant of Regnitio, formerly a regulator at EMA with 18 years of experience in regulatory roles.
Regnitio
Episode: A Visit with Andrew Thomson
Janet Wittes
Statistician with extensive experience in clinical trials and biostatistics.
Statistics Collaborative
Episode: A Visit with Dr. Janet Wittes
Frank Harrell
Professor and founding chair of the Department of Biostatistics at Vanderbilt University.
Vanderbilt University
Episode: Bayesian Clinical Trials with Frank Harrell
Dr. Derek Angus
Distinguished professor and chair of Critical Care Medicine at the University of Pittsburgh.
University of Pittsburgh
Episode: A Visit with Dr. Derek Angus
Michael Proschan
Mathematical statistician at NIH specializing in clinical trials
NIH, NIAID
Episode: A Discussion with Michael Proschan on Response-Adaptive Randomization

Hosts

Scott Berry
Host with a focus on statistical science and clinical trials, providing insights on Bayesian methodologies and adaptive designs.
Scott Evans
Co-host frequently engaging in discussions around clinical trial design and regulatory frameworks.

Chart Rankings

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Talking Points

Recent interactions between the hosts and their guests.

Bayesian Statistics in Clinical trials: The Past, Present, and Future
Q: Are there ethical concerns in giving a patient treatment with a prior probability that's lower than a different treatment?
Yes, and the clinical trial community tries to maintain treatment equalities by randomizing trials, which can obscure ethical considerations.
Bayesian Statistics in Clinical trials: The Past, Present, and Future
Q: So, Scott, leading into around the year 2000, when you and Don founded Berry, where was your head at with the I-Spy 2 trial?
At that time, there was uncertainty regarding the utility of Bayesian clinical trials, but over the years, they have proven effective despite initial challenges.
Teaching Statistics and Data Science through Sports with Dr. Jim Albert
Q: What skill set should someone interested in sports statistics focus on as an undergraduate?
They need a background in statistics and modeling, some experience in the sport, and the ability to communicate their work effectively.
The Time Machine
Q: How do you model time in a trial?
You can model time independently or smooth the estimates, depending on the data intervals.
The Time Machine
Q: Why would anybody care about a time machine in clinical trials?
It's about making relative comparisons to the old and new standards of care within platform trials.

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Frequently Asked Questions About In the Interim...

What is In the Interim... about and what kind of topics does it cover?

This podcast focuses on the realm of statistical science and clinical trials, with a particular emphasis on Bayesian statistics and adaptive trial methodologies. Each episode explores complex medical challenges, offering insights and discussions that push beyond traditional paradigms in clinical research. The content is driven by conversations with industry leaders who provide expert perspectives on innovative strategies for enhancing trial outcomes, ensuring patient safety, and navigating regulatory landscapes. Themes such as clinical trial design, statistical methodologies, and the integration of real-world data into research are prevalent, making it an invaluable resource for professionals in the pharmaceutical sector and beyond.

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3. The Daily
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In the Interim... launched 10 months ago and published 40 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

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Recent guests on In the Interim... include:

1. Kaspar Rufibach
2. Jeff Saver
3. Don Berry
4. Dr. Jim Albert
5. Andrew Thomson
6. Janet Wittes
7. Frank Harrell
8. Dr. Derek Angus

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