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Artwork for Longevity Roadmap

Longevity Roadmap

Buck Joffrey
Intermittent Fasting
Fasting
Time-Restricted Eating
Nutrition
Longevity Diet
Metabolic Health
Autophagy
Health Optimization
Gut Microbiome
Stem Cells
Longevity
Mental Health
Sleep
Cardiovascular Disease
Diabetes
Gerontology
Cancer Research
Dysbiosis
Digestive Health
Human Papillomavirus

Dr. Buck Joffrey sits down with leading scientists in the field of longevity to explore cutting-edge research, emerging therapies, and what it really takes to live longer—healthier.

PublishesWeeklyEpisodes167Founded3 years ago
Number of ListenersCategories
Alternative HealthHealth & Fitness

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Artwork for Longevity Roadmap

Latest Episodes

Aging begins when cellular quality-control systems lose their precision.

In this episode, Professor Ana Maria Cuervo outlines how chaperone-mediated autophagy (CMA)—a selective lysosomal degradation pathway essential for proteostasis—progressively ... more

In this episode, we are joined by Dr. Tony Wyss-Coray to discuss his groundbreaking research on brain resilience and aging.

He explains how systemic factors, particularly proteins in the blood, influence cognitive function and the aging process.

... more

In this episode, we are joined by Dr. Francisco González-Lima to delve into the metabolic mechanisms that drive brain aging and cognitive decline.

He begins by outlining how reductions in cytochrome oxidase activity, disruptions in oxidative phosph... more

We are joined by behavioral epidemiologist Dr. Kate Wolin to unpack why so many health interventions collapse outside the lab—and what actually drives lasting change in the real world.

From frictionless habit design and daily self-monitoring to mov... more

Key Facts

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Recent Guests

Ana Maria Cuervo
Professor and world-renowned cell biologist focusing on autophagy and aging
Albert Einstein College of Medicine
Episode: 165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Dr. Tony Wyss-Coray
Leading researcher on systemic factors governing aging in the brain
Stanford University
Episode: 164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray
Dr. Francisco González-Lima
George I. Sanchez Centennial Professor at the University of Texas at Austin, internationally recognized for his pioneering work on brain energy metabolism, mitochondrial function, and the role of cytochrome oxidase in cognition, memory, and aging.
University of Texas at Austin
Episode: 163: How Mitochondrial Decline Drives Brain Aging with Dr. Francisco Gonzalez-Lima
Dr. Kate Wolin
Behavioral epidemiologist, entrepreneur and digital health innovator with over two decades of experience.
Episode: 162: The Habits of Healthy Aging with Dr. Kate Wolin
Dr. Jennifer Elisseeff
Morton Goldberg Professor at Johns Hopkins University and Director of the Translational Tissue Engineering Center.
Johns Hopkins University
Episode: 161: The Future of Tissue Regeneration with Dr. Jennifer Elisseeff
Dr. Heidi Tissenbaum
Professor of Molecular Cell and Cancer Biology at UMass Chan Medical School, recognized for her work on C. elegans and pathways influencing lifespan.
UMass Chan Medical School
Episode: 160: Molecular Secrets of Aging Told Through Worms with Dr. Heidi Tissenbaum
Jan Vijg
Chair of genetics at Albert Einstein College of Medicine and pioneer in genetic mutations related to aging.
Albert Einstein College of Medicine
Episode: 159: How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg
Dr. Keith Diaz
Florence Irving Associate Professor of Behavioral Medicine at Columbia University and expert on the effects of prolonged sitting.
Columbia University
Episode: 158: Sitting Is the New Smoking with Dr. Keith Diaz
Mitchell Roslin
Chief of Bariatric Surgery at Lenox Hill Hospital, New York, Professor of Surgery at the Zucker School of Medicine at Hofstra Northwell
Episode: 157: The Role of Surgery in Diabetes and Obesity with Dr. Mitchell Roslin

Host

Buck Joffrey
Host specializing in longevity, discussing cutting-edge research with experts across health and wellness domains.

Reviews

5.0 out of 5 stars from 43 ratings
  • Brief Bites of Health

    Dr. Joffrey collects experts in various health fields and provides an overview with directions within a 20-30 minute interview. He’s an excellent interviewer and explains complex concepts with analogies and he asks the questions I have as a listener. Excellent podcast!

    Apple Podcasts
    5
    georgep909
    United States2 years ago
  • Interesting content in an engaging format

    As a follower and investor with WealthFormula for the last several years, I really appreciate the content of Sapio to help me enjoy a long, healthy life to go along with the healthy returns on my investments. Each program compliments the other. Buck does a great job of keeping the content informative and entertaining. Great material for the masses.

    Apple Podcasts
    5
    Ferwhatitsworth
    United States2 years ago
  • Interesting

    The information provided is interesting, informative and actionable. This podcast provides good information and keeping healthy and longevity in a concise conversation. I really enjoyed learning some new information about health and staying healthy. They provide good information with a very positive spin.

    Apple Podcasts
    4
    Aacapello
    United States2 years ago
  • The Best

    I have been following Buck for 5 years now and invest with him in multi family. He always has great content and he has continued it with this new series on how to live longer and better to enjoy the money we make through investing.

    Thanks Buck!!

    Tony C

    Apple Podcasts
    5
    TonyJC@777
    United States2 years ago
  • Couple questions

    Amazing podcast ! Been following your wealth formula podcast for a while and now Sapio! Huge fan! Couple questions: wanted to see if you could dive little bit deeper into key differences as far as what you would recommend for women; more specifically when talking about managing cholesterol, as statins are generally not recommend for child-bearing age.

    And also when you talk about spikes when monitoring blood glucose levels, are you looking to avoid reaching certain number of blood glucose or ju... more

    Apple Podcasts
    5
    Nikki Quiroz
    United States2 years ago

Listeners Say

Key themes from listener reviews, highlighting what works and what could be improved about the show.

The engaging format and conversational style make it accessible, likening it to having a knowledgeable friend explain complex health science.
Several comments highlight the practical value of the information offered, suggesting it is actionable and relevant for improving personal health.
Listeners note the high-quality content that aligns well with their interests in longevity and wellness, often expressing gratitude for the practical insights shared.
Many listeners appreciate the clarity and depth of interviews featuring expert guests from various scientific fields, enhancing their understanding of health topics.

Top Alternative Health Podcasts

Talking Points

Recent interactions between the hosts and their guests.

165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Q: What are some of the promising future therapeutic strategies you are exploring?
We are investigating small molecules that mimic or increase the levels of CMA receptors, along with potential gene therapies.
165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Q: What lifestyle interventions can help preserve CMA activity?
Interventions include reducing refined sugar intake, ensuring adequate sleep, and engaging in regular exercise to activate autophagy.
165: Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo
Q: What drives the decline of chaperone-mediated autophagy (CMA) activity with age?
It is a combination of genetic programs winding down, environmental factors, and metabolic changes over time.
164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray
Q: What kinds of patterns determine those who maintain cognitive sharpness late in life versus those who decline?
Studies show that proteins in the spinal fluid can predict cognitive resilience or decline, and similar signatures in blood are being investigated.
164: Young Blood Can Rejuvenate Old Brains with Dr. Tony Wyss-Coray
Q: How do you begin to disentangle correlation versus causation?
To determine causation, researchers can observe healthy individuals before disease onset, utilize genetic tools, and ultimately test in clinical trials.

Audience Metrics

Listeners, social reach, demographics and more for this podcast.

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Frequently Asked Questions About Longevity Roadmap

What is Longevity Roadmap about and what kind of topics does it cover?

Discussions center around innovative research and therapies related to longevity and health, featuring insights from leading scientists and experts. Common topics include the science of aging at the cellular and systemic levels, as well as practical tools for promoting healthier, longer lives. Additionally, the conversations often explore emerging scientific discoveries and their potential implications for enhancing human longevity, making the content appealing to those interested in health science, personal wellness, and the latest in medical research.

Where can I find podcast stats for Longevity Roadmap?

Rephonic provides a wide range of podcast stats for Longevity Roadmap. We scanned the web and collated all of the information that we could find in our comprehensive podcast database. See how many people listen to Longevity Roadmap and access YouTube viewership numbers, download stats, audience demographics, chart rankings, ratings, reviews and more.

How many listeners does Longevity Roadmap get?

Rephonic provides a full set of podcast information for three million podcasts, including the number of listeners. View further listenership figures for Longevity Roadmap, including podcast download numbers and subscriber numbers, so you can make better decisions about which podcasts to sponsor or be a guest on. You will need to upgrade your account to access this premium data.

What are the audience demographics for Longevity Roadmap?

Rephonic provides comprehensive predictive audience data for Longevity Roadmap, including gender skew, age, country, political leaning, income, professions, education level, and interests. You can access these listener demographics by upgrading your account.

How many subscribers and views does Longevity Roadmap have?

To see how many followers or subscribers Longevity Roadmap has on Spotify and other platforms such as Castbox and Podcast Addict, simply upgrade your account. You'll also find viewership figures for their YouTube channel if they have one.

How many episodes of Longevity Roadmap are there?

Longevity Roadmap launched 3 years ago and published 167 episodes to date. You can find more information about this podcast including rankings, audience demographics and engagement in our podcast database.

How do I contact Longevity Roadmap?

Our systems regularly scour the web to find email addresses and social media links for this podcast. We scanned the web and collated all of the contact information that we could find in our podcast database. But in the unlikely event that you can't find what you're looking for, our concierge service lets you request our research team to source better contacts for you.

Where can I see ratings and reviews for Longevity Roadmap?

Rephonic pulls ratings and reviews for Longevity Roadmap from multiple sources, including Spotify, Apple Podcasts, Castbox, and Podcast Addict.

View all the reviews in one place instead of visiting each platform individually and use this information to decide if a show is worth pitching or not.

How do I access podcast episode transcripts for Longevity Roadmap?

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What guests have appeared on Longevity Roadmap?

Recent guests on Longevity Roadmap include:

1. Ana Maria Cuervo
2. Dr. Tony Wyss-Coray
3. Dr. Francisco González-Lima
4. Dr. Kate Wolin
5. Dr. Jennifer Elisseeff
6. Dr. Heidi Tissenbaum
7. Jan Vijg
8. Dr. Keith Diaz

To view more recent guests and their details, simply upgrade your Rephonic account. You'll also get access to a typical guest profile to help you decide if the show is worth pitching.

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